Abstract #300014


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JSM 2002 Abstract #300014
Activity Number: 189
Type: Invited
Date/Time: Tuesday, August 13, 2002 : 10:30 AM to 12:20 PM
Sponsor: Section on Statistics in Epidemiology*
Abstract - #300014
Title: Association Studies for Human Trait Genes -- Promise and Practice
Author(s): Jurg Ott*+
Affiliation(s): Rockefeller University
Address: Box 192, 1230 York Avenue, New York, New York, 10021, USA
Keywords: quality of life ; environmental factors ; biological factors ; genetic factors ; quality of life
Abstract:

The search for genes underlying complex traits has been difficult and often disappointing. The main reason for these difficulties is that several genes, each with rather small effect, are presumambly interacting to produce the trait. For genome-wide case-control association studies, we recently developed a simple strategy that circumvents many of the current problems such as inflated false positive rates and genotyping errors (Hoh et al [2001] Genome Res 11:2115-2119). The newly developed methodology combines relevant parameters such as linkage disequilibrium and Hardy-Weinberg disequilibrium into a single-marker statistic for each marker. Information is combined over multiple markers in the genome through summing over single-marker statistics. The significance level of such a sum is evaluated with permutation tests. In applications to data sets our approach has shown highly significant results, while conventional marker-by-marker analysis was nonsignificant.


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