Abstract #301895

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JSM 2002 Abstract #301895
Activity Number: 23
Type: Contributed
Date/Time: Sunday, August 11, 2002 : 2:00 PM to 3:50 PM
Sponsor: Biopharmaceutical Section*
Abstract - #301895
Title: Rank-Based Methods for Clinical Trials With Unbalanced Repeated Measures Data
Author(s): Mushfiquar Rashid*+
Affiliation(s): Food and Drug Administration
Address: 5600 Fishers Lane, HFD-715, Rockville, Maryland, 20857, USA
Keywords: Dispersion function ; Gradient vector ; R-estimators ; F-test ; Simulation
Abstract:

We develop a rank-based analysis of clinical trials with unbalanced repeated measures data. We assume that the errors within each subject are exchangeable random variables. This rank-based inference is valid when the unbalanced data are missing either completely at random or by design. A drop in dispersion test is developed for general linear hypotheses. A numerical example is given to illustrate the procedure. A small scale simulation study is performed in order to compare the performances of the rank-based test and the normal theory F test.

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Revised March 2002