Activity Number:
|
81
|
Type:
|
Contributed
|
Date/Time:
|
Monday, August 12, 2002 : 8:30 AM to 10:20 AM
|
Sponsor:
|
Biometrics Section*
|
Abstract - #301031 |
Title:
|
A Statistical Model for Investigating Binding Probabilities of DNA Nucleotide Sequences Using Microarrays
|
Author(s):
|
Mei-Ling Lee*+ and George Whitmore
|
Affiliation(s):
|
Harvard University and McGill University
|
Address:
|
181 Longwood Ave, Boston, Massachusetts, 02115, USA
|
Keywords:
|
gene expression ; microarrays ; log-linear probabilities
|
Abstract:
|
There is considerable scientific interest in knowing the probability that a given site-specific transcription factor will bind to a given DNA sequence. Microarray methods provide an effective means for assessing the binding affinities of a large number of DNA sequences, as demonstrated by Bulyk et al (2001a) in their study of the DNA-binding specificities of Zif268 zinc fingers using microarray technology.
We present a general statistical methodology for analyzing microarray intensity measurements reflecting DNA-protein interactions.
|