Activity Number:
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82
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Type:
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Contributed
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Date/Time:
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Monday, August 12, 2002 : 8:30 AM to 10:20 AM
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Sponsor:
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Biopharmaceutical Section*
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Abstract - #300919 |
Title:
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Imputation for Instrument With Item Nonrespondents in Clinical Research
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Author(s):
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Hansheng Wang*+ and Shein-Chung Chow and Ying Zhang
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Affiliation(s):
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Principal Statistician and StatPlus, Inc. and StatPlus, Inc.
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Address:
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1790 Yardley-Langhorne RD, Yardley, Pennsylvania, 19067, USA
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Keywords:
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Item nonrespondents ; imputation ; jackknife
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Abstract:
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An imputation approach for instrument with item nonrespondents in clinical research is proposed. The proposed method provides consistent estimators, which are asymptotically normal. A jackknife procedure is also proposed to estimate the asymptotic variance of the derived estimators. A simulation study was conducted to study the finite sample performance of the derived estimators. Simulation results indicated that the finite sample distribution of the derived estimators can be well-approximated by its asymptotic distribution with a moderate sample size. It also shows that the estimators based on the imputed data set are more efficient than the estimator based on the completers.
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