JSM Activity #9

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Activity ID:  9
Title Room
Evaluating Resistance in Infectious Disease Trials M-Madrid/Trinidad
Date / Time Sponsor Type
08/05/2001    2:00 PM  -  3:50 PM WNAR, ENAR Invited
Organizer: Victor DeGruttola, Harvard School of Public Health
Chair: Victor De Gruttola, Harvard School of Public Health
Discussant: 3:20 PM - Mark Segal, University of California, San Francisco    
Floor Discussion 3:35 PM
Description

A major concern in the treatment of both bacterial and viral infections is the eventual development of drug-resistant strains, with adverse clinical consequences. Recent technological advances allow characterization of drug resistance both in genotypic and phenotypic terms. Processing this information appropriately in the context of a patient's treatment regimen raises a number of interesting statistical challenges. One suggestion for this session is to have the same dataset (from a trial in HIV-positive subjects) analyzed by three different participants/approaches.
  300115  By:  Andrea Foulkes 2:05 PM 08/05/2001
Characterizing the Relationship Between HIV-1 Genotype and Phenotype: Prediction Based Classification

  300419  By:  Francoise Seillier-Moisewitsch 2:30 PM 08/05/2001
Looking for Linked Resistance Mutations in HIV

  300420  By:  Brendan Larder 2:55 PM 08/05/2001
The Use of Pattern Recognition and Neural Network Techniques to Identify HIV-1 Reverse Transcriptase Mutations that are the Common Cause of Nucleoside Cross Resistance.

JSM 2001

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Revised March 2001