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Title
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Room
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Adaptive Modification of Sample Size in Clinical Trials
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M-London/Zurich
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Date / Time
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Sponsor
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Type
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08/09/2001
10:30 AM
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12:20 PM
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Biometrics Section*, ENAR
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Invited
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Organizer:
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Michael Proschan, National Heart, Lung, and Blood Institute
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Chair:
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Michael Proschan, National Heart, Lung, and Blood Institute
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Discussant:
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11:50 AM - Dean Follmann, National Heart Lung and Blood Institute
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Floor Discussion
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12:15 PM
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Description
An essential component in the planning of a clinical trial is the determination of sample size, which depends on the size of the treatment effect. Sometimes it is not clear what the minimum clinically relevant treatment difference is. What if it becomes clear that the initially hypothesized treatment effect was incorrect? Is the trial doomed, or can the sample size be changed? This session presents valid methods of adaptively modifying sample size and/or design of clinical trials.
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