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Invited Session

Target Trial Emulation for Health Policy Evidence Using Observational Data: Methodological Innovations, Reproducible Workflows, and Novel Applications

Fri, Jan 15, 10:30 AM - 12:15 PM

Saskia ComessOrganizerSummer HanChair

5 Abstracts

Target trial emulation: "Standard" non-randomized study design, or something more?

Elizabeth Stuart (Johns Hopkins University, Bloomberg School of Public Health)

observational study non-experimental study causal inference reporting guidelines

Promises and Pitfalls of Target Trial Emulation for Health Policy Evaluation

Nicholas Seewald (University of Pennsylvania)

study design target trials

A Simulation and Analysis Pipeline for Real-World Evidence Generation Using Target Trial Emulation

Saskia Comess (Stanford University)

target trial emulation observational studies simulation reproducibility

Target Trial Emulation for Health Policy Evidence: Federated Counterfactual Digital Twins and Reproducible Multisite Workflows

Yong Chen (University of Pennsylvania School of Medicine)

target trial emulation; real-world data; electronic health records; reproducibility; digital twins; simulation

From ITT to Per-Protocol: Navigating Estimand Choice in Target Trial Emulation

Lucia Petito (Northwestern University, Feinberg School of Medicine)

estimand per-protocol marginal structural models real-world evidence target trial emulation

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