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The investigation of Acute Kidney Injury in a South African ICU (307921)

Keywords: Acute Kidney Injury, Logistic regression, Survival Analysis

Acute Kidney Injury (AKI) is frequently encountered in the Intensive Care Unit (ICU) and is associated with high mortality and morbidity. AKI has been well characterised in high income countries and appears to be increasing in incidence. However, there is a noticeable scarcity of data from sub-Saharan African ICU’s regarding the incidence and effect of AKI on mortality and functional renal recovery, where the prevalence of HIV and trauma is high and where resources are often limited. The current studies on AKI in the sub-Saharan Africa are often limited by either small sample sizes, retrospective design or failure to follow up on longer-term outcomes. Hence, the primary objective of this study is to prospectively investigate the occurrence and outcomes of AKI in a closed multi-disciplinary ICU in South Africa. In particular, the logistic regression model was used to investigate risk factors associated with AKI. The effect of AKI on mortality and hospital survival was assessed using the logistic regression model and survival analysis, respectively. According to the knowledge of the authors, this is the large prospective study on AKI in sub-Saharan Africa.