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Thursday, January 11
Thu, Jan 11, 2:00 PM - 3:45 PM
Crystal Ballroom A
Meta-Analysis and Systematic Review

Estimating population effects using meta-analysis (304283)

*Hwanhee Hong, Johns Hopkins Bloomberg School of Public Health 

Meta-analysis with RCTs is commonly used to evaluate treatments and inform policy decisions because it provides the best summaries of all available evidence. However, meta-analyses are limited to draw population inference of treatment effects because they usually do not define target populations of interest specifically and results of the individual RCTs in those meta-analyses may not generalize to target populations. We extend generalizability methods for a single RCT to meta-analysis with individual participant-level data. We apply these methods to generalize meta-analysis results from RCTs of treatments on schizophrenia to adults with schizophrenia who present to usual care settings in the US.