Adaptive Designs: One Reviewer’s Perspective
*Pablo E. Bonangelino, FDA/CDRH Keywords: Adaptive Designs: One Reviewer’s Perspective. I will first give a reviewer’s perspective on the important operational issue of the study accrual rate in its relation to adaptive designs. I will then discuss the statistical approach of optimal alpha, which is based on considering the total error, that is, both alpha and beta, when arriving at a statistical decision. Two examples will be given. The optimal alpha approach will be seen to potentially have important implications for adaptive designs where the concern is an inflated Type I error rate. I will conclude with possible directions for future research related to this approach.
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Key Dates
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April 30 - May 22, 2013
Invited Abstract Submission Open -
June 4, 2013
Online Registration Opens -
August 9 - August 23, 2013
Invited Abstract Editing -
August 23, 2013
Short Course materials due from Instructors -
August 26, 2013
Housing Deadline -
September 9, 2013
Cancellation Deadline and Registration Closes @ 11:59 pm EDT -
September 16 - September 18, 2013
Marriott Wardman Park, Washington, DC