TL45: Mediators and Moderators in Randomized Clinical Trials
*Qing Liu, Johnson & Johnson Janssen Research & Development, LLC Isaac Nuamah, Janssen R&D Christine Blasey, Corcept Therapeutics and Stanford University Keywords: Datasets for clinical trials provide an opportunity to analyze both moderators and mediators of the treatment effect. Because multiple models exist which define these correlates of treatment response, there is often disagreement regarding how to statistically test for mediators and moderators. We will discuss and share ideas regarding how to conduct such analyses(e.g. the McArthur model, Barron and Kenny), and how to use the results to guide future trials.
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Key Dates
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April 30 - May 22, 2013
Invited Abstract Submission Open -
June 4, 2013
Online Registration Opens -
August 9 - August 23, 2013
Invited Abstract Editing -
August 23, 2013
Short Course materials due from Instructors -
August 26, 2013
Housing Deadline -
September 9, 2013
Cancellation Deadline and Registration Closes @ 11:59 pm EDT -
September 16 - September 18, 2013
Marriott Wardman Park, Washington, DC