Some Practical Considerations in the Implementation of Adaptive Clinical Trials in Pharmaceutical Development Programs
View Presentation *Dennis W King, STATKING Clinical Services Keywords: Adaptive Trials Adaptive designs have received much attention in the statistical literature and are being more commonly employed in drug development programs. While the application of these designs is theoretically sound, there are many practical considerations that must be considered before implementing these designs in practice. In this presentation, we will examine some of the components that are key in the execution of adaptive designs. Two examples will be covered: a Phase I study of a laser treatment for brain tumors and a Phase III study adaptive design with an interim analysis that involved potential stopping for futility or superiority as well as a sample size re-estimation for continuation of the trial.
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Key Dates
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April 30 - May 22, 2013
Invited Abstract Submission Open -
June 4, 2013
Online Registration Opens -
August 9 - August 23, 2013
Invited Abstract Editing -
August 23, 2013
Short Course materials due from Instructors -
August 26, 2013
Housing Deadline -
September 9, 2013
Cancellation Deadline and Registration Closes @ 11:59 pm EDT -
September 16 - September 18, 2013
Marriott Wardman Park, Washington, DC