TL39: Missing Data: Alternatives to Imputation
*Bob Abugov, FDA Keywords: Missing data, imputation, retrieval study Missing data adds uncertainty to results from clinical trials originally intended to definitively assess efficacy & safety. Methods have been developed to impute missing data. However, the very data needed to validate the assumptions of any imputation is, by definition, missing. So the appropriateness of any given imputation often becomes questionable. Starting from this point, we will discuss alternatives to imputation. For example: 1. What alternatives are there to imputation? 2. How do the estimands from a valid imputation differ from those of a study in which imputation is not performed? 3. How do the estimands from a valid imputation differ from those of a data retrieval study? 4. Is no imputation actually a form of imputation?
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Key Dates
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April 30 - May 22, 2013
Invited Abstract Submission Open -
June 4, 2013
Online Registration Opens -
August 9 - August 23, 2013
Invited Abstract Editing -
August 23, 2013
Short Course materials due from Instructors -
August 26, 2013
Housing Deadline -
September 9, 2013
Cancellation Deadline and Registration Closes @ 11:59 pm EDT -
September 16 - September 18, 2013
Marriott Wardman Park, Washington, DC