Participants at this roundtable will discuss real world experiences in the implementation of adaptive trials. Statisticians who have actually conducted adaptive trials are welcome. Statisticians who are about to conduct adaptive trials are welcome to learn from the "veterans". Topics include: roles and responsibilities of an unblinded statistician, data lag, working with several data sources, and managing communications of unblinded information, randomization and drug supply. If a discussion leader from the FDA were interested in joining. he/she would be most welcome.