Examining heterogeneity in treatment response in clinical trials: The poor man’s mxture model analysis
View Presentation *Kathleen W. Wyrwich, UnitedBioSource Corporation Keywords: responder definition, clinical trials, hereogeneity In clinical trials and observational studies, post-hoc analyses provide an excellent opportunity to explore unknown or unstudied associations between the endpoints and patient characteristics measures during the trial using logistic regression. To employ this method, each endpoint needs to be dichotomized, and a reasonable responder definition or threshold needs to be selected for classifying each trial participant as improved vs. about the same or got worse on the outcome of interest. Once classified, a multiple logistic regression results can identify important patient attributes strongly associated with the outcome, as well as test interaction variables when crossed with treatment group assignment that are associated with outcomes.
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Key Dates
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April 30 - May 22, 2013
Invited Abstract Submission Open -
June 4, 2013
Online Registration Opens -
August 9 - August 23, 2013
Invited Abstract Editing -
August 23, 2013
Short Course materials due from Instructors -
August 26, 2013
Housing Deadline -
September 9, 2013
Cancellation Deadline and Registration Closes @ 11:59 pm EDT -
September 16 - September 18, 2013
Marriott Wardman Park, Washington, DC