Some Liabilities of Kappa Measure of Agreement between Two Imaging Diagnostics
*Anthony G Mucci, FDA/CDER 

Keywords: Kappa , Sensitivity, Specificity

The objective of this presentation is to provide natural families of cases where two competing diagnostics present high Kappa levels but divergent sensitivity and specificity performances. These examples are intended as cautionary, since they indicate that Kappa is sometimes inadequate to ensure the desired similarities in diagnostic performance. If these cases are pervasive, then measures alternative to Kappa should be proposed and evaluated.