Sample Size Re-estimation: Technical and Practical Problems
*Kuang-Kuo Gordon Lan, Johnson & Johnson PRD Keywords: clinical trials, control of alpha In this talk, we will discuss the pros and cons of the weighted Z and the unweighted Z tests proposed for data analysis after sample size re-estimation in clinical trials. The weighted Z approach has been studied extensively by statistical researchers in the last 10 years, but many clinicians are hesitant to employ this test for comparisons of treatments. The sequential computed weighted Z tests can control the alpha level easily, but it violates the one-patient-one-vote principle. The weighted Z test, on the other hand, usually requires extensive simulations to justify alpha control. In this presentation, I will give in detail the motivation of the unweighted Z approach, and the penalty involved in practice.
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Key Dates
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April 30 - May 22, 2013
Invited Abstract Submission Open -
June 4, 2013
Online Registration Opens -
August 9 - August 23, 2013
Invited Abstract Editing -
August 23, 2013
Short Course materials due from Instructors -
August 26, 2013
Housing Deadline -
September 9, 2013
Cancellation Deadline and Registration Closes @ 11:59 pm EDT -
September 16 - September 18, 2013
Marriott Wardman Park, Washington, DC