Adaptive Designs for Dose Ranging Studies
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*Vladimir Dragalin, Wyeth Research 

Keywords: Adaptive designs, Bayesian, dose-ranging studies

PhRMA Working Group on Adaptive Dose Ranging Studies is considering a set of new adaptive designs, based on both frequentist and Bayesian methodologies. We will present the results of a comprehensive simulation study that compares the performance (operating characteristics) of these new designs and the designs previously considered in the White Paper of the Working Group published in the Journal of Biopharmaceutical Statistics, 2007.