Thresholding of a Companion Diagnostic test Confident of Efficacy in Targeted Population
*Yi Liu, Takeda Pharmaceuticals Keywords: There are two different perspectives on personalized medicine. One perspective is to optimize selecting a treatment for each individual patient among existing treatments, on average. The other perspective, the setting of this presentation, is to develop a new drug that would provide new benefit to a subgroup of patients. That is, patients in this subgroup will do better under this new treatment on average than under the Standard of Care. We will show how to correctly infer efficacy in the subgroup of patients whose biomarker value is above a certain threshold while maintaining the logical relationship among the parameters. We will also show how to find the “optimal” threshold from a new drug development perspective.
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Key Dates
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June 3, 2014 - September 7, 2015
Online Registration -
June 3, 2015 - August 15, 2015
Housing -
July 31 - August 17, 2015
Invited Abstract Editing -
August 10, 2015
Short Course materials due from Instructors -
August 26, 2015
Advanced Registration Deadline -
September 7, 2015
Cancellation Deadline -
September 16 - 18, 2015
Marriott Wardman Park, Washington, DC