TL2: Enriching patient population by response: placebo run-in, randomized withdrawal, sequential parallel comparison design (SPCD) and twice enriched design (TED).
*Anastasia Ivanova, University of North Carolina at Chapel Hill Keywords: placebo run-in, randomized withdrawal, sequential parallel comparison design (SPCD) We discuss various ways to lower the impact of high placebo response on the success of a clinical trial. Existing proposals used in practice include (1) placebo or active lead-in designs and (2) the sequential parallel comparison design (SPCD) where the trial is conducted in two stages with each stage being sufficiently long to observe the outcome.
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Key Dates
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June 3, 2014 - September 7, 2015
Online Registration -
June 3, 2015 - August 15, 2015
Housing -
July 31 - August 17, 2015
Invited Abstract Editing -
August 10, 2015
Short Course materials due from Instructors -
August 26, 2015
Advanced Registration Deadline -
September 7, 2015
Cancellation Deadline -
September 16 - 18, 2015
Marriott Wardman Park, Washington, DC