Adaptive Designs to Demonstrate Risk Reduction in CV Outcome Trials
View Presentation *Cyrus R Mehta, President Keywords: safety study, reduction of cardiovascular risk, promising zone, type-2 diabetes It is now mandatory to demonstrate that new antihyperglycemic drugs do not elevate cardiovascular risk. The current approach to demonstrate CV safety is through an event-driven trial with adequate power for the upper confidence bound of the 95% confidence interval of the hazard ratio to be below 1.3. It would be desirable, however, to prolong a trial that has satisfied the 1.3 threshold in the expectation of concluding, eventually, that the hazard ratio is below 1. We shall show how this can be achieved in a statistically valid manner, with minimal risk of unnecessary trial prolongation, through an adaptive "promising zone" design. As no antihyperglycemic agent has so far shown actual risk reduction, the first agent to do so would enjoy tremendous competitive advantage besides benefiting the large population with type-2 diabetes. We will illustrate our approach with the help of the recently completed EXAMINE trial (NEJM, September 2014) a group sequential trial of patients with acute coronary syndrome treated with alogliptin.
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Key Dates
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November 1 - December 17, 2013
Online proposal submission for a session, short course and Town Hall Open -
January 6 - March 11, 2014
Online proposal submission for Roundtables Open -
April 30 - May 28, 2014
Abstract Submission Open -
June 4, 2014
Online Registration Opens -
August 8 - August 22, 2014
Invited Abstract Editing -
August 11, 2014
Short Course materials due from Instructors -
September 1, 2014
Housing Deadline -
September 15, 2014
Cancellation Deadline and Registration Closes @ 11:59 pm EDT -
September 22 - September 24, 2014
Marriott Wardman Park, Washington, DC