Issues in analyzing time-to-event endpoint involving non-proportional hazard
Kun He, FDA Rajeshwari Sridhara, US Food and Drug Administration *Vivian Yuan, FDA Keywords: non-proportional hazard, time-to-event Cox’s (1972) proportional hazards model has become a popular tool in the analysis of time-to-event endpoints in clinical trials. However, there are many cases where hazard ratios are not constant over time and the treatment effect may be transient. In this talk we will present some of the critical issues in the analysis of data when the proportional hazard assumption is violated, and present some case examples.
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Key Dates
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November 1 - December 17, 2013
Online proposal submission for a session, short course and Town Hall Open -
January 6 - March 11, 2014
Online proposal submission for Roundtables Open -
April 30 - May 28, 2014
Abstract Submission Open -
June 4, 2014
Online Registration Opens -
August 8 - August 22, 2014
Invited Abstract Editing -
August 11, 2014
Short Course materials due from Instructors -
September 1, 2014
Housing Deadline -
September 15, 2014
Cancellation Deadline and Registration Closes @ 11:59 pm EDT -
September 22 - September 24, 2014
Marriott Wardman Park, Washington, DC