Covariate-adaptive randomization -- a preferred randomization method in clinical trials
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*Bob Zhong, Johnson and Johnson 

Keywords: clinical trials, randomization, covariate-adaptive randomization, balance.

Covariate-adaptive randomization has been used in clinical trials for about 40 years. There are many controversies around it. Some like it a lot; others strongly discourage the use of it. Is it the time to make a conclusion now? The latest research results demonstrate that many “discussed” concerns associated with covariate-adaptive randomization are unfounded. On the contrary, these results support that covariate-adaptive randomization should be the preferred and recommended randomization method for randomized clinical trials, small or large.