Tailored Multi-Strata Designs for Early Phase Clinical Trials
View Presentation *Beat Neuenschwander, Novartis Pharma AG Satrajit Roychoudhury, Novartis Pharmaceutical Keywords: Exchangeability, Multi-strata In clinical trials statistical challenges arise when data from different strata (e.g. trials, regions, populations, cancer type) are available. Statistical inference for strata-specific parameters can be challenging due to the uncertainty about whether or not (or to what degree) pooling across strata is appropriate. We propose EXNEX, a tailored and robust multi-strata approach that allows for different degrees of exchangeability (EX) as well as non-exchangeability (NEX) across strata parameters. The proposed methodology will be discussed with examples from phase I and II Oncology trials.
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Key Dates
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November 1 - December 17, 2013
Online proposal submission for a session, short course and Town Hall Open -
January 6 - March 11, 2014
Online proposal submission for Roundtables Open -
April 30 - May 28, 2014
Abstract Submission Open -
June 4, 2014
Online Registration Opens -
August 8 - August 22, 2014
Invited Abstract Editing -
August 11, 2014
Short Course materials due from Instructors -
September 1, 2014
Housing Deadline -
September 15, 2014
Cancellation Deadline and Registration Closes @ 11:59 pm EDT -
September 22 - September 24, 2014
Marriott Wardman Park, Washington, DC