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The Association Between Vitamin D Deficiency and Diabetes in African Americans and Whites (305306)
*Alula Hadgu, Morehouse School of Medicine
Robert Mayberry, Morehouse School of Medicine
Fengxia Yan, Morehouse School of Medicine
Keywords: Propensity score matching, inverse probability of treatment weighing, sampling weights, vitamin D deficiency, diabetes.
In this study we investigated the association between vitamin D deficiency (VDD) and diabetes in African Americans (AAs) and Whites. This analysis is based on the recent National Health and Nutrition Examination Surveys with VDD measurement. We developed propensity score models based on matching (PSM) and inverse probability of treatment weighing (IPTW). We performed covariate balance using standardized mean differences. The prevalence of diabetes for AAs and Whites were 12.27% (95% CI: 10.58 -14.19%) and 7.24% (95% CI: 6.48-8.12%), respectively. The prevalence of VDD for AAs and Whites were 65.29% (95% 61.94 - 68.50%) and 19.49% (95% CI: 16.70-22.62%), respectively. The crude odds ratios for the diabetes-VDD association for AAs and Whites were 0.81 (95% CI: 0.62-1.06) and 2.13 (95% CI: 1.62 -2.80), respectively. Under PSM, the diabetes-VDD odds ratios for AAs and Whites were 0.94 (95% CI: 0.70-1.27) and 2.16 (95% CI: 1.49 -3.13), respectively. The results under the IPTW algorithm were similar to the results obtained using PSM. VDD and diabetes are more prevalent in AAs compared to Whites. However, VDD was associated with increased diabetes risk for Whites but not for AAs.