St. James Ballroom
Finding Simultaneous Tolerable Dosage Combinations for Multiple Endnotes (303850)
*Faten Saeed Alamri, Virginia Commonwealth University & Princess Nourah Bint Abdulrahman University
Keywords: Bayesian, tolerable region, continues multiple endpoints.
Everyone is exposed to chemicals in modern society as most workplaces, homes, farms, markets use some form of chemical to address pests, spoilage, sanitation, etc., and assessing and controlling the risk is of paramount importance. In particular, agriculture has a high risk due to fertilizers and pesticides, which may contain hazardous chemicals. Farmers are interested in determining a proper treatment (dose) of chemicals to eliminate pests but want a dosage that still permits a safe work environment. This work develops a statistical framework to determine the tolerable region that has low doses of chemicals and minimal side effects using a Bayesian design of experiments approach. A novel approach to follow up designs using the variance of the tolerable region when parametric models are used is presented. The work considers various scenarios that could be confronted in the real world to demonstrate the method for obtaining design points that minimize the variance of the resulting tolerable region. This approach considers multiple outcomes and multiple stressors.