Online Program

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Thursday, September 13
Thu, Sep 13, 1:15 PM - 2:30 PM
Thurgood Marshall North
Challenges in Designing a Master Protocol: Platform, Umbrella, and Basket Designs

Basket and Umbrella Trials: Definitions, Properties, Examples, and Challenges (300707)

*Lindsay A. Renfro, University of Southern California 

Keywords: trial design, basket trial, umbrella trial

Within the field of clinical cancer research, discovery of biomarkers and genetic mutations that are potentially predictive of treatment benefit are motivating a paradigm shift in how cancer clinical trials are conducted. In this talk, I will provide an overview of basket and umbrella trials, which are increasingly popular design solutions for the study of novel targeted agents. For each, I will describe standardized terminology, discuss scientific and practical advantages and limitations, and provide a detailed real-world example.