All Times EDT
Keywords: Win Ratio; Composite Endpoint; Hierarchical
In clinical trials, such as cardiovascular trials, hierarchical composite endpoints combining mortality and other non-fatal endpoints are often used. Different type of endpoints may be combined to measure the treatment effect.
The win ratio approach was introduced in 2012 (Pocock et al., 2012) as a new method for examining composite endpoints which compares patients in the treated group with those in the control group in a pairwise fashion. Compared to conventional methods for analyzing composite endpoints, the win ratio accounts for relative priorities of the components recognizing clinical importance of different components of the composite endpoint.
The win ratio approach has been widely adopted since introduction. During the roundtable, topics to be discussed will include application of the win ratio analysis in clinical trial design, components of the composite endpoints, implementation of intercurrent events handling rules, etc.