There is an increase in sources of post-marketing safety data which are becoming more easily and readily available, including spontaneous reporting systems, real world, and social medial data sources. This also includes data from an influx of electronic medical and healthcare records (EMR/EHR) and digital sensors in leading to newer forms of safety data. This has heightened the need to identify new approaches to analyze and present these data in some insightful way. The various sources of safety data coupled with readily available high-speed computing resources have opened new frontiers and opportunities for the assessment of drug safety and require somewhat non-traditional programming and visualization approaches. Visual analytics present a useful alternative to tabular outputs for exploring these safety data and present a great opportunity to enhance and facilitate evaluation of drug safety and convey multiple pieces of information concisely and more effectively than tables, blending data visualization, statistical and data mining techniques. In this talk, we will discuss some of the approaches and open source and online tools that can be leveraged for visual analytics of safety data from post-marketing data sources, including, spontaneous reporting systems, social media sources, and electronic medical and healthcare records.