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Activity Number:
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374
- Bayesian Clinical Trial Designs with Heterogeneous Patient Subgroups
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Type:
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Topic Contributed
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Date/Time:
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Wednesday, August 10, 2022 : 8:30 AM to 10:20 AM
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Sponsor:
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Biopharmaceutical Section
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Abstract #320929
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Title:
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Dose Finding with Heterogeneous Patient Subgroups
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Author(s):
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ANASTASIA IVANOVA* and Pooja Saha
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Companies:
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UNC at Chapel Hill and Center for Biostatistics in AIDS Research, Department of Biostatistics, Harvard T.H. Chan
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Keywords:
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Subgroups;
CRM;
POCRM
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Abstract:
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In a dose-finding trial with heterogeneous subgroups, it can be unclear how to order responses to new therapy across subgroups and dose levels. We extend the partial order CRM (POCRM) for use with a continuous outcome through the quasi-Bernoulli likelihood. We show how to use the POCRM to find the recommended phase 2 dose defined as the dose with mean response equal to a pre-specified value of a continuous response biomarker.
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Authors who are presenting talks have a * after their name.
