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Activity Number:
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26
- Imaging Speed Session
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Type:
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Contributed
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Date/Time:
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Sunday, August 8, 2021 : 1:30 PM to 3:20 PM
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Sponsor:
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Section on Statistics in Imaging
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Abstract #319009
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Title:
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CoCoA: A Conditional Correlation Model with Association Size
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Author(s):
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Danni Tu* and Bridget Mahony and Maxwell A. Bertolero and Aaron F Alexander-Bloch and Danielle S. Bassett and Theodore D Satterthwaite and Armin Raznahan and Russell Shinohara
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Companies:
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Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania and Section on Developmental Neurogenomics, National Institutes of Mental Health and Department of Psychiatry, Perelman School of Medicine and University of Pennsylvania and Department of Bioengineering, University of Pennsylvania and University of Pennsylvania and Developmental Neurogenomics Unit, National Institute of Mental Health and University of Pennsylvania
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Keywords:
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Dynamic correlation;
Speed-accuracy tradeoff;
Cognitive performance;
GEE
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Abstract:
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In tasks that measure cognitive function, the trade-off between speed and accuracy requires that the two be studied together. A natural question is whether speed-accuracy coupling depends on other variables, such as sustained attention. Classical regression techniques, which make different assumptions about the covariates and outcome, are insufficient to investigate the effect of a third variable on the symmetric relationship between speed and accuracy. In response, we propose CoCoA (Conditional Correlation Model with Association Size), a statistical framework that adapts second-order generalized estimating equations inspired by genome association studies to estimate the conditional correlation as a function of additional variables. We further propose novel measures of the association size, which are analogous to effect sizes on the correlation scale, while adjusting for confounding. Using neurocognitive data from the Human Connectome Project, we demonstrate that greater sustained attention in a working memory task is associated with stronger speed-accuracy coupling while controlling for age.
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Authors who are presenting talks have a * after their name.
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