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Activity Number:
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29
- Statistical Issues Specific to Therapeutic Areas, Power and Sample Size Calculations, and Trial Monitoring
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Type:
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Contributed
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Date/Time:
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Sunday, August 8, 2021 : 1:30 PM to 3:20 PM
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Sponsor:
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Biopharmaceutical Section
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Abstract #319031
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Title:
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WITHDRAWN: Comparison of Methods for Adjusting for Crossover in Oncology Trials
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Author(s):
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Jin Zhang
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Companies:
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Merck
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Keywords:
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Crossover;
Oncology;
Survival
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Abstract:
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In randomized oncology trials, patients in the control arm are sometimes permitted to switch to receive experimental drug after disease progression. While progression-free survival is not usually impacted by crossover, the treatment effect on overall survival can be highly confounded. The rank-preserving structural failure time (RPSFT) model is one of the most widely used model. In this presentation, we compare the performance of RPSFT and other competing methods for correcting the impact of treatment switching on overall survival.
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Authors who are presenting talks have a * after their name.
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