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Activity Number:
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209
- Statistical methods for genomic and epigenetic data analysis
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Type:
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Contributed
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Date/Time:
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Tuesday, August 10, 2021 : 1:30 PM to 3:20 PM
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Sponsor:
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Section on Statistics in Genomics and Genetics
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Abstract #318926
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Title:
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Genetic Correlation Between Major Depression and Objectively Assessed Sleep Features in a Community Cohort from Lausanne, Switzerland
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Author(s):
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Wei Guo* and Sun J Kang and Giorgio Pistis and Lihong Cui and Andrew Leroux and Vadim Zipunnikov and Martin Preisig and Kathleen Merikangas
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Companies:
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National Institutes of Health and National Institutes of Health and Lausanne University Hospital and University of Lausanne and NIMH and University of Colorado Anschutz Medical Campus and Johns Hopkins Bloomberg School of Public Health and University Hospital of Lausanne and National Institute of Mental Health
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Keywords:
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actigraphy;
major depression;
sleep
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Abstract:
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Sleep patterns are a core feature of Major Depression, but the extent to which they are risk factors versus consequences has not been fully examined. The use of accelerometers to obtain objective measures of sleep with actigraphy provides an opportunity to examine this association in real time. In this paper, we investigate whether genetic factors underlying sleep duration are associated with Major depression in a community based cohort of adults. The sample includes 2274 adults, ages 35-75 years old Cohort Study of Lausanne, Switzerland (CoLaus) who wore Geneactiv acceleromters for at least 12 days. Clinical diagnoses were based on clinician administered diagnostic interviews for the full spectrum of mental disorders. We utilized Polygenic Risk Scores (PRSs) to examine the genetic association between depression and sleep features derived from actigraphy. PRS derived from PGC-for major depression was significantly associated with sleep duration in in the CoLaus sample. However, the phenotypic variance explained was relatively small (R2 = 0.335%, P=5×10^(-3)). Future analyses will examine other sleep feature as well as their overlap with PRS for Major Depression.
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Authors who are presenting talks have a * after their name.
