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Activity Number:
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25
- Medical Devices and Diagnostics Speed Session
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Type:
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Contributed
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Date/Time:
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Sunday, August 8, 2021 : 1:30 PM to 3:20 PM
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Sponsor:
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Section on Medical Devices and Diagnostics
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Abstract #318609
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Title:
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On the Noninferiority McNemar Test
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Author(s):
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Zhigang Zhang*
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Companies:
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Memorial Sloan-Kettering Cancer Center
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Keywords:
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McNemar Test;
Non-inferiority Design;
Sample Size Determination;
Power Calculation
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Abstract:
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The McNemar test is commonly used for comparing two dependent proportions arising from paired or matched individuals. In this study we thoroughly examine the McNemar test under the non-inferiority setting. We show that the usual conditional test bears a systematic bias while the unconditional test does not. We also derive sample size formula for practical usage when designing trials. Both theoretical considerations and numerical studies are carried out for establishing large sample properties and illustrating finite sample performance.
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Authors who are presenting talks have a * after their name.
