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Abstract:
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Obesity is a prevalent chronic condition in many developed and developing nations that raises the risk for the development of non-communicable diseases such as cardiovascular diseases, type 2 diabetes (T2D), musculoskeletal disorders, and some cancers. Recent studies indicate that fermented fibers and probiotics are associated with improvements in metabolic responses in obesity and diabetes. This research examines tissue and systemic metabolic responses to supplementation with type 2 resistant starch and/or probiotic Lactobacillus in obese mice fed a high-fat diet. Results show that these dietary supplementations are associated with improvements in the obese and diabetic phenotype. A lot of attention in recent decades raises to infer connectivity between measurements in metabolic alternations. Copula directional dependence has adopted to measure and to visualize the directed connectivity, which does not require strict assumptions on probability distributions and linearity.
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