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Activity Number:
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429
- Strategic Statistical Partnerships Impacting Health and Education for the Public Good
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Type:
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Invited
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Date/Time:
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Thursday, August 6, 2020 : 10:00 AM to 11:50 AM
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Sponsor:
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Stats. Partnerships Among Academe Indust. & Govt. Committee
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Abstract #309318
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Title:
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Furthering Public Health Through the Fred Hutchinson Cancer Research Center/Sanofi Pasteur Dengue Vaccine Collaboration
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Author(s):
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Zoe Moodie and Peter Gilbert and Michal Juraska and Ying Huang* and Youyi Fong and Brenda Price and Carlos DiazGranados and Stephen Savarino and Saranya Sridhar and Edith Langevin and Tifany Machabert and Ming Zhu
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Companies:
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Fred Hutchinson Cancer Research Center and Fred Hutchinson Cancer Research Center and Fred Hutchinson Cancer Research Center and Fred Hutchinson Cancer Research Center and Fred Hutchinson Cancer Research Center and University of Washington and Sanofi Pasteur and Sanofi Pasteur and Sanofi Pasteur and Sanofi Pasteur and Sanofi Pasteur and Sanofi Pasteur
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Keywords:
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correlate of risk;
vaccine;
optimal surrogate;
academia-industry partnership;
bridging;
data sharing
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Abstract:
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Since the partnership’s formation in 2013, Fred Hutchinson (FH) has been a strategic partner in planning and developing Sanofi Pasteur’s dengue vaccine program. FH statisticians have been actively engaged in this collaboration by providing input on Phase 3 trial design, providing support at the advisory and regulatory meetings, and developing and applying novel statistical approaches for the analysis of the emerging data. In particular, we developed models quantifying how neutralizing antibody titers measured at baseline and post vaccination predict subsequent dengue disease and correlate with the vaccine efficacy (VE), and developed novel methods to extrapolate VE to older populations beyond the age range of the trial populations.
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Authors who are presenting talks have a * after their name.
