Big Data Distributed System for Phenome and Genome Management and Analysis in a Large Health System Wendy Wong, Inova Translational Medicine Institute; Xinyue Liu, Inova Translational Medicine Institute; Prachi Kothiyal, Inova Translational Medicine Institute; Wei Zhu, Inova Translational Medicine Institute; Fang Zhou, Inova Translational Medicine Institute; Shan Gao, Inova Translational Medicine Insitute; Sakthi Madhappan, Inova Translational Medicine Institute; Lin Smith, Inova Translational Medicine Institute; Henry Hunter, Inova Translational Medicine Institute; Aaron Black, Inova Translational Medicine Institute; John F Deeken, Inova Translational Medicine Institute; John E Niederhuber, Inova Translational Medicine Institute