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Abstract:
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The Transmission Disequilibrium Test (TDT) compares frequencies of transmission of two alleles from heterozygote parents to an affected offspring. This test requires all genotypes to be known from parents and an offspring. However, obtaining all genotypes in a study might not be possible in some cases. The techniques of imputing only missing parental genotypes or ignoring missing parental genotypes but considering unaffected and affected offspring genotypes have been proposed. Mendelian Inheritance TDT (MITDT-ONE) is a new method that controls type I error well, uses Mendelian Inheritance property, and takes population frequency of disease allele and marker allele into account.
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