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Activity Number: 299 - SPEED: Recent Advances in Statistical Genomics and Genetics
Type: Contributed
Date/Time: Tuesday, July 31, 2018 : 8:30 AM to 10:20 AM
Sponsor: Biometrics Section
Abstract #329441
Title: Subset Testing and Analysis of Multiple Phenotypes
Author(s): Andriy Derkach* and Ruth Pfeiffer
Companies: National Cancer Institute and National Cancer Institute
Keywords: meta-analysis; mixture model; gene based test; heterogeneity

Meta-analysis of multiple genome-wide association studies (GWAS) is effective for detecting single or multi marker associations with complex traits. We develop a flexible procedure based on mixture models to perform region based meta-analysis of different phenotypes using data from different GWAS and identify subsets of associated phenotypes. Our model framework helps distinguish true associations from between-study heterogeneity. As a measure of association we compute for each phenotype the posterior probability that the genetic region under investigation is truly associated. Extensive simulations show that our method is more powerful than standard approaches for meta analyses when the proportion of truly associated outcomes is less than 50. For other settings, the power of STAMP is similar to that of existing methods. We illustrate our method on two examples, the association of a region on chromosome 9p21 with risk of fourteen cancers.

Authors who are presenting talks have a * after their name.

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