|
Abstract:
|
Based on a NICE document (December 2016), this presentation highlights recommendations for use of population-adjusted indirect comparisons. These recommendations cover five areas: 1) the rationale for the use of population adjustment in NICE submissions, 2) justifying the use of population adjustment in both anchored and unanchored scenarios, 3) variables for which population adjustment is required, 4) generation of indirect comparison for the appropriate target population, and 5) reporting guidelines for analyses involving population adjustment. Research recommendations are given about the need for alternative approaches to population-adjusted indirect comparison and population-adjusted network meta-analysis intended to overcome the limitations of existing methods and, given this, the need for a plan on a comprehensive set of simulation studies, empirical studies, and illustrative applications of the new methods.
|
