Activity Number:
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650
- On the Use of Computer-Intensive Methods in Pharmaceutical Research
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Type:
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Topic Contributed
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Date/Time:
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Thursday, August 3, 2017 : 10:30 AM to 12:20 PM
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Sponsor:
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Biopharmaceutical Section
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Abstract #324063
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View Presentation
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Title:
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On the Use of Empirical Bayes Techniques to Bridge from an in Vitro System to a Clinical Trial
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Author(s):
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Ya Meng* and Camille Salamand and Robert D. Small
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Companies:
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Sanofi Pasteur and Sanofi Pasteur and Sanofi Pasteur
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Keywords:
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Mimic Technology ;
Bayesian Modeling ;
Clinical Trials ;
In Vitro Study ;
Pre-Clinical ;
Vaccine
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Abstract:
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The MIMIC system allows for human experiments to be done in vitro and subjects to be treated with multiple treatments which are not possible in clinical trials. Instead of the typical animal studies, the system can evaluate human immune responses during the pre-clinical period without safety concerns. The objective is to investigate a Bayesian modeling which uses the study information from MIMIC as prior information to the analyses of a clinical trial from the same vaccine candidate. Benefits from MIMIC technology are fully described and results present a potential usage of MIMIC study.
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Authors who are presenting talks have a * after their name.