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Activity Number: 263
Type: Contributed
Date/Time: Monday, August 1, 2016 : 2:00 PM to 3:50 PM
Sponsor: Biopharmaceutical Section
Abstract #321486
Title: Statistical Analysis of the Progression of Tumors in Rats
Author(s): Mary Esther Nevener* and Cynthia Murray and Wei Chen
Companies: University of Central Oklahoma and University of Central Oklahoma and University of Central Oklahoma
Keywords:
Abstract:

The research team at the University of Central Oklahoma studied the combination of lasers and immunotherapy on tumor-bearing rats. Their cancer treatment involved three components: laser immunotherapy (LIT), Cyclophosphamide (CY), and Glycated Chitosan (GC). Rats in Group 1 had LIT (10 minutes), GC, and CY; Group 2 had LIT (5 minutes), GC, and CY; and Group 3 received only CY. Data pertaining to the tumors was analyzed using the Kaplan-Meier survival method to determine if there was a difference in "time to failure" distributions with the variation of treatment. Three time intervals (days) were computed: time between tumor inoculation and disappearance of the primary tumor, time between disappearance of the primary tumor and recurrence, and time between inoculation and metastasis. Tumor outcomes were categorized as either a failure or censored observation. Censored observations occurred if there was no failure by either the end of the study or when the rat was euthanized. For each of the three computed time intervals, there was no significant difference (p>0.05) between treatment groups with regard to the estimated survival distributions.


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