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Activity Number: 137
Type: Contributed
Date/Time: Monday, August 1, 2016 : 8:30 AM to 10:20 AM
Sponsor: Biopharmaceutical Section
Abstract #321083
Title: A New Design for Drug Combination in Phase I Dose-Finding Clinical Trials
Author(s): Jim Xiang* and Grace Liu and James Pan
Companies: Janssen and Johnson & Johnson and Janssen
Keywords: Dose finding ; Combination drugs ; Clinical trials ; Simulation
Abstract:

We consider finding maximum tolerated doses (MTDs) from combination of two agents when the dose-safety profiles for each of agents are known. One such situation is that both agents are currently marketed and being used in the medical practice. In this talk, we present a new and efficient design to find the MTDs from combined treatments. Simulations are conducted for varieties of scenarios and comparisons are made to some existing methods.


Authors who are presenting talks have a * after their name.

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