Activity Number:
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137
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Type:
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Contributed
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Date/Time:
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Monday, August 1, 2016 : 8:30 AM to 10:20 AM
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Sponsor:
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Biopharmaceutical Section
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Abstract #321083
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Title:
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A New Design for Drug Combination in Phase I Dose-Finding Clinical Trials
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Author(s):
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Jim Xiang* and Grace Liu and James Pan
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Companies:
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Janssen and Johnson & Johnson and Janssen
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Keywords:
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Dose finding ;
Combination drugs ;
Clinical trials ;
Simulation
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Abstract:
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We consider finding maximum tolerated doses (MTDs) from combination of two agents when the dose-safety profiles for each of agents are known. One such situation is that both agents are currently marketed and being used in the medical practice. In this talk, we present a new and efficient design to find the MTDs from combined treatments. Simulations are conducted for varieties of scenarios and comparisons are made to some existing methods.
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Authors who are presenting talks have a * after their name.