Activity Number:
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339
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Type:
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Topic Contributed
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Date/Time:
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Tuesday, August 2, 2016 : 10:30 AM to 12:20 PM
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Sponsor:
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WNAR
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Abstract #320526
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Title:
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Integrated DNA Mutation, Copy Number, and Gene Expression Analysis Reveals a Highly Reproducible Prognostics Marker in Lung Adenocarcinomas
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Author(s):
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Hao Ho*
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Companies:
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University of California at Los Angeles
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Keywords:
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Liquid Association ;
Cancer study ;
Integrative data analysis ;
Copy number ;
Gene expression
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Abstract:
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In cancer genome, mutation and copy number alteration (CNA) are important regulators of gene expression. Many of the existing methods are limited by omitting nonlinear effects. We proposed a novel approach adopting a modified liquid association (LA) score to explore the complex interaction effects. Liquid association score was introduced to measure the average change in the covariation of two variables as a third continuous variable varies. A modified LA score was designed for studying the change of effect between copy number and gene expression conditioned on different mutation status as a binary variable. We applied our method using EGFR mutation status as a master regulator alone with genome-wide copy number and gene expression of 159 lung adenocarcinomas from National Taiwan University Hospital and Taichung Veterans General Hospital. Our method revealed four EGFR mutant/wild-type specific conditional CNA-correlated differentially expressed genes. Using the Cox proportional hazards model, we identified one gene's over-expression is associated with poor overall survival and this result was validated in three independent cohorts.
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Authors who are presenting talks have a * after their name.
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