Online Program Home
My Program

Abstract Details

Activity Number: 491
Type: Contributed
Date/Time: Wednesday, August 3, 2016 : 8:30 AM to 10:20 AM
Sponsor: Section on Statistics in Genomics and Genetics
Abstract #320382 View Presentation
Title: ASAFE: Ancestry-Specific Allele Frequency Estimation
Author(s): Qian Zhang* and Brian Browning and Sharon Browning
Companies: University of Washington and University of Washington and University of Washington
Keywords: GWAS ; Admixed Population ; Local Ancestry ; Hispanics ; EM Algorithm ; Allele frequency
Abstract:

In a genome-wide association study (GWAS) of an admixed population, such as Hispanic Americans, ancestry-specific allele frequencies can inform the design of a replication GWAS. We derive an EM algorithm to estimate ancestry-specific allele frequencies for a bi-allelic marker given genotypes and local ancestries on a 3-way admixed population, when the phase of each admixed individual's genotype relative to the pair of local ancestries is unknown. We call our algorithm Ancestry Specific Allele Frequency Estimation (ASAFE). We demonstrate that ASAFE has low error on simulated data.


Authors who are presenting talks have a * after their name.

Back to the full JSM 2016 program

 
 
Copyright © American Statistical Association