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Abstract:
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Long-range chromatin interactions based on chromosome folding involve bringing physically separated functional elements into close proximity. In particular, interaction between distant enhancers and promoters is an essential mechanism for transcriptional regulation of genes. We hypothesize that, in breast cancer cell lines, upon hormone/chemo treatment, the interactions between transcriptional regulation regions and promoters for target genes that are sensitive to treatment will alter significantly. We developed a Mixture Beta-Binomial model imbedded in the saturated empirical Bayesian Framework to characterize chromosome folding, and identify potential target genes as well significant interactions genome widely.
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