Online Program Home
My Program

Abstract Details

Activity Number: 639
Type: Topic Contributed
Date/Time: Thursday, August 4, 2016 : 8:30 AM to 10:20 AM
Sponsor: Biopharmaceutical Section
Abstract #318960 View Presentation
Title: A Flexible Model for Dose Escalation in Phase I Trials
Author(s): Ying Lu* and Shenghua Kelly Fan and Bee Leng Lee and Yanyan Song
Companies: Palo Alto VA Health Care System/Stanford University and California State University at East Bay and San Jose State University and Shanghai Jiao Tong University
Keywords: Phase I Trial ; Dose Limiting Toxicity ; Birth Death Process ; Dose Escalation ; Continous Reassessment Methods ; Simulation
Abstract:

Chiang and Conforti (1989, Mathematical Biosciences, pp:1-29) used the birth and death processes to describe the remaining toxicants (RT) in human body and defined cancer incidence rate as a function of RT to build a model for time to cancer. We use their idea to build the distribution for time to dose-limiting-toxicity in phase I trials. The model is flexible to accommodate a single, sequential, or combinational use of different drugs. Continuous reassessment methods can be then developed under the model. We discuss the properties of our approaches via simulation studies.


Authors who are presenting talks have a * after their name.

Back to the full JSM 2016 program

 
 
Copyright © American Statistical Association