Activity Number:
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557
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Type:
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Contributed
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Date/Time:
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Wednesday, August 3, 2016 : 10:30 AM to 12:20 PM
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Sponsor:
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Section on Statistical Consulting
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Abstract #318911
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Title:
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Piecewise Growth Curve Modeling for the Hypothermia Study of Mice
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Author(s):
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Jingyi Zhang* and Frank Lawrence and Claire Hankenson and Ania Skorupski
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Companies:
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Michigan State University and Michigan State University and Michigan State University and Michigan State University
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Keywords:
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piecewise growth curve model ;
hypothermia study ;
animal science
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Abstract:
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1786 observations were made up of 6 groups of mice, each representing a different level of treatment. The control group and 4 of the treatment groups had 8 mice each measured at 38 different occasions. One group consisted of 7 mice measured at 38 one minute intervals. Each treatment group was measured for 7 minutes at one minute intervals before treatment was administered. The purpose of this hypothermia study is to investigate the effects of 5 scrubbing ways (treatments) on the change of core and surface temperatures of mice. A 2-level piecewise growth curve model is proposed to capture the trajectories of temperatures for both the pre-treatment and post-treatment periods. For the post-treatment trajectory, a growth curve that allowed for acceleration (or deceleration) and a change in acceleration was used. In Level 2 model, we considered the effects of treatment and weight of mice. We also examined the correlation between core and surface temperatures to figure out whether these two responses could be used interchangeably.
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Authors who are presenting talks have a * after their name.