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Activity Number: 557
Type: Contributed
Date/Time: Wednesday, August 3, 2016 : 10:30 AM to 12:20 PM
Sponsor: Section on Statistical Consulting
Abstract #318911
Title: Piecewise Growth Curve Modeling for the Hypothermia Study of Mice
Author(s): Jingyi Zhang* and Frank Lawrence and Claire Hankenson and Ania Skorupski
Companies: Michigan State University and Michigan State University and Michigan State University and Michigan State University
Keywords: piecewise growth curve model ; hypothermia study ; animal science
Abstract:

1786 observations were made up of 6 groups of mice, each representing a different level of treatment. The control group and 4 of the treatment groups had 8 mice each measured at 38 different occasions. One group consisted of 7 mice measured at 38 one minute intervals. Each treatment group was measured for 7 minutes at one minute intervals before treatment was administered. The purpose of this hypothermia study is to investigate the effects of 5 scrubbing ways (treatments) on the change of core and surface temperatures of mice. A 2-level piecewise growth curve model is proposed to capture the trajectories of temperatures for both the pre-treatment and post-treatment periods. For the post-treatment trajectory, a growth curve that allowed for acceleration (or deceleration) and a change in acceleration was used. In Level 2 model, we considered the effects of treatment and weight of mice. We also examined the correlation between core and surface temperatures to figure out whether these two responses could be used interchangeably.


Authors who are presenting talks have a * after their name.

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