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Activity Number: 178
Type: Contributed
Date/Time: Monday, August 1, 2016 : 10:30 AM to 12:20 PM
Sponsor: Biopharmaceutical Section
Abstract #318888
Title: A Bayesian Approach for Classification Based on Continuous Glucose Monitoring Data of Diabetic Patients
Author(s): Hui Zheng*
Companies: Harvard Medical School
Keywords: Bayesian ; Spline ; classification ; continuous glucose monitoring ; diabetes ; CGM
Abstract:

We propose a Bayesian modeling approach to distinguish subgroups of diabetic patients based on their glucose profiles. The glucose data are collected using continuous glucose monitoring (CGM) devices which measure glucose at a frequency of once 1 to 5 minutes. The classification method is based on a hierarchical model using B-spline basis functions to smooth the glucose measurements while allowing for auto-correlations. In the training phase, the mean and variance-covariance matrices of glucose profiles are obtained for each subgroup. The classification is based the posterior probabilities for a patient to belong to each subgroup. We illustrate the method using CGM data collected in a clinical trial .


Authors who are presenting talks have a * after their name.

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