Testing Repeated Measured Microbiome Data and Phylogenetic Tree

• Activity Number: 254
• Type: Contributed
• Date/Time: Monday, August 10, 2015 : 2:00 PM to 3:50 PM
• Sponsor: Biometrics Section
• Author(s): Pixu Shi* and Hongzhe Li
• Companies: University of Pennsylvania and University of Pennsylvania
• Keywords: Dirichlet-Multinomial ; Microbiome ; Paired multivariate count data ; Phylogenetic tree ; Testing

Abstract

We propose a new probability distribution for paired multivariate count data based on Dirichlet-Multinomial distribution. The new distribution can manage cross sample correlation for repeatedly measured multivariate count data that often arises in microbiome research. Based on this new distribution, we introduce a statistic to test the difference of two groups of multivariate count data with paired observations. We also provide a new way to test group difference in phylogenetic tree data with count reads instead of normalized proportions.